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Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. 2015 Nov; 22(11):1837-45. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. 2005 Mar; 39(3):181-8. Hepatic porphyrias. 2012 Nov; 122(11):4280-2. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. Differentiation. 1998 Feb; 2(1):77-102, vi. J Gastroenterol. J Clin Invest. J Hepatol. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. J Surg Res. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Front Mol Biosci. Am J Physiol. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 2011 Jan; 53(1):4-6. J Clin Invest. 2000 Mar; 15 Suppl:D20-5. Mol Cell Biol. 2000 Dec; 32(6):1272-9. 2014 Jul 21; 5:4451. 2019 03; 156(4):1156-1172.e6. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. 2005 Feb; 115(2):209-18. 1992 Sep 04; 70(5):777-89. Methods Mol Biol. 2008 Aug; 42(5):349-61. Cell Mol Gastroenterol Hepatol. Clin Gastroenterol Hepatol. 2010 Jul; 139(1):323-34.e7. 2005 Jun 10; 280(23):21763-72. 2010 Jul; 26(4):395-402. 2005 Sep; 230(8):573-86. Leadership - Institute for Diabetes and Metabolic Health - UC San 2007 Nov; 2(4):243-4. J Biol Chem. 2007 Nov; 46(5):1443-52. Streetz K, Leifeld L, Grundmann D, Ramakers J, Eckert K, Spengler U. Kupffer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Inactivation of myofibroblasts during regression of liver fibrosis. 2013 Feb 01; 12(3):381-2. Nat Commun. 1994 Sep; 14 (9):5950-60. 2001 Nov; 281(5):G1279-89. Gastroenterology. Rippe RA, Schrum LW, Stefanovic B, Sols-Herruzo JA. 2010 Mar; 51(3):1027-36. Meng F, Wang J, Ge J, Fan X, Wang B, Han L. Innate immunity in alcoholic liver disease. 2019 03 29; 10(1):1406. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Circulation. 2011 Jul; 179(1):189-98. Genomics of liver fibrosis and cirrhosis. 1997 May; 25(5):1128-35. J Clin Gastroenterol. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. J Biol Chem. 2001 Jul 01; 167(1):173-80. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. J Exp Med. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the Combatting Fibrosis: Exosome-Based Therapies in the Regression of Liver Fibrosis. 2008 Apr 15; 5(3):338-42. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Int J Mol Med. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. J Biol Chem. Mechanisms of liver fibrosis and its role in liver cancer. Am J Physiol Gastrointest Liver Physiol. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2000 Sep 29; 275(39):30597-604. Hepatology. Hepatology. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 2020 Apr; 4(4):606-626. Am J Physiol Gastrointest Liver Physiol. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. J Theor Biol. Hepatology. New therapies for hepatic fibrosis. 1993 Dec; 92(6):2916-21. Gastroenterology. Hepatology. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Gastroenterology. Nephron. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. Liver Int. Hepatology. Molecular defects in ferrochelatase in patients with protoporphyria requiring liver transplantation. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Mol Cell Biol. 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